GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.

This trial is comparing two treatments for vaginal dryness, itching, and pain during sex in breast cancer survivors who are taking hormone-blocking therapy (endocrine therapy). These symptoms — called vaginal or vulvar atrophy — are common side effects of anti-estrogen treatments. The study tests whether one treatment works better than the other without affecting breast cancer outcomes. **You may be eligible if...** - You have been diagnosed with breast cancer - You are currently on endocrine therapy (an aromatase inhibitor or SERM) - You are postmenopausal (no period for 12 months, or other confirmed criteria) - You have one or more symptoms of vaginal dryness, painful intercourse, or irritation **You may NOT be eligible if...** - You have had prior vaginal or vulvar surgery (hysterectomy is allowed) - You currently have another vaginal or vulvar disease - You used antibiotics, antifungals, or corticosteroids in the past month - You are currently using vaginal hormones or moisturizers (you may be eligible after a 4-week washout period) Talk to your doctor to see if this trial is right for you.