Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
Region Skane
3,500 participants
Aug 17, 2023
INTERVENTIONAL
Conditions
Summary
The STEPCARE-trial is a 2x2x2 randomised trial studying patients who have been resuscitated from cardiac arrest and who are comatose. It will include three different interventions focusing on sedation targets, temperature targets and mean arterial pressure targets.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
If core body temperature exceeds 37.7°C a feedback controlled-device will be used and set at 37.5°C.
A MAP target of \>85mmHg will be used. Vasopressors will be titrated to this target during 36h.
Deep sedation for at least 36h
Management of fever in the ICU without a device
A MAP target of \>65mmHg will be used. Vasopressors will be titrated to this target during 36h.
A strategy of minimal sedation in the ICU, used only as needed to facilitate transport, imaging and invasive procedures.
Locations(56)
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NCT05564754