RecruitingNot ApplicableNCT05568264

Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit

Early Detection and Therapeutic Improvement of Motor Delay in High Risk Infants: A Randomized, Controlled Trial


Sponsor

Shirley Ryan AbilityLab

Enrollment

222 participants

Start Date

Oct 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Study Aims Pilot study: Due to the large recruitment goal and length of the project, the study team/PIs will evaluate the first cohort of 6-10 participants to refine study procedures and study-related materials. If no major modifications are made to the protocol as a result of this evaluation, data from these participants will be included for analysis. Aim 1: Evaluate the efficacy of an early, evidence-based, clinical experience-based therapeutic intervention (from the NICU to 12-months corrected age) on improving motor function and reducing severity of motor delays in infants at 12-months corrected age. The investigators hypothesize that the intervention group will demonstrate an average 8-point difference (0.5 standard deviation) compared to the standard of care group. \[an 8-point difference is considered a clinically meaningful difference\] Aim 2: Evaluate the early effects (i.e., before 12 months) of a therapeutic intervention, provided from NICU to 12-months corrected age, on motor function and severity of motor delay. The Investigators hypothesize that a statistically significant higher percentage of infants in the intervention group will demonstrate improved motor function and reduced severity of motor delays, compared to the standard of care group-assessed using sensors, the NSMDA and TIMP-as early as 3-months corrected age. Aim 3: Evaluate whether an early intervention that focuses on caregiver engagement improves caregiver well-being. The invetigators hypothesize that an intervention that focuses on supporting and addressing the individual needs of the caregiver will improve caregiver well-being. The investigators will evaluate these effects using the PedsQL (Family Impact Module).


Eligibility

Min Age: 33 WeeksMax Age: 48 Weeks

Plain Language Summary

Simplified for easier understanding

This study tests whether a physical therapy program started in the NICU (neonatal intensive care unit) and continued afterward can reduce or prevent motor delays in high-risk premature or sick newborns. The therapy includes guided movement exercises and uses sensor-based monitoring to track progress. You may be eligible if (for the infant): - The baby was admitted to the NICU - The baby qualifies due to: birth weight under 1,500 grams, a brain injury or developmental abnormality, or bronchopulmonary dysplasia (chronic lung disease in preemies) - The baby is medically stable - Intervention can begin between 34 and 48 weeks postmenstrual age (corrected gestational age) You may NOT be eligible if: - The baby has open wounds or skin conditions preventing sensor placement - The baby requires protective isolation due to immune deficiency - The baby has limb reduction defects, bleeding disorders, or is receiving anticoagulants - The baby is in palliative or hospice care - No English-speaking caregivers are available - The family is involved with DCFS (child protective services) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPhysical Therapy intervention

The intervention is based on five principles: active learning, caregiver engagement, environmental enrichment, strengths-based approach, and dose. The intervention will start in the NICU and continue until 12-months corrected age. Infants in the intervention group will receive up to two therapist visits per week in addition to standard of care physical therapy. Caregivers will be asked to work with their infant on activities provided by the therapist. The therapist will provide resources to support the caregiver in working on these activities with their child, and caregivers will be asked to complete the activities for as much time as possible, throughout the day. Therapists will work with caregivers to identify ways to incorporate activities into their day. Caregiver engagement and caregiver ability to complete sessions and activity recommendations will be monitored.


Locations(3)

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, United States

Northwestern Medicine Prentice Children's Hospital

Chicago, Illinois, United States

Children's Hospital at the University of Illinois

Chicago, Illinois, United States

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NCT05568264


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