Hypoxic-ischemic encephalopathy. Clinical Trials

17 recruitingLast updated: May 5, 2026

There are 16 actively recruiting hypoxic-ischemic encephalopathy. clinical trials across 6 countries. Studies span Not Applicable, Phase 2, Early Phase 1, Phase 1, Phase 4. Top locations include San Diego, California, United States, Orlando, Florida, United States, Gainesville, Florida, United States. Updated daily from ClinicalTrials.gov.


Hypoxic-ischemic encephalopathy. Trials at a Glance

16 actively recruiting trials for hypoxic-ischemic encephalopathy. are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in San Diego, Orlando, and Gainesville. Lead sponsors running hypoxic-ischemic encephalopathy. studies include Baylor College of Medicine, Children's Hospital Los Angeles, and BDH-Klinik Hessisch Oldendorf.

Browse hypoxic-ischemic encephalopathy. trials by phase

Treatments under study

About Hypoxic-ischemic encephalopathy. Clinical Trials

Looking for clinical trials for Hypoxic-ischemic encephalopathy.? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Hypoxic-ischemic encephalopathy. trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Hypoxic-ischemic encephalopathy. clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 116 of 16 trials

Recruiting

Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)

TBITBI (Traumatic Brain Injury)Hemodynamic Instability+2 more
Children's Hospital Los Angeles1,000 enrolled1 locationNCT06195345
Recruiting
Phase 4

Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates

HypotensionAsphyxiaCirculatory Failure Neonatal+1 more
Semmelweis University50 enrolled1 locationNCT05836610
Recruiting
Phase 2

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

Hypoxic-ischemic encephalopathy.
ReAlta Life Sciences, Inc.70 enrolled15 locationsNCT05778188
Recruiting
Phase 1

Dose Optimization of Caffeine for HIE

Hypoxic-ischemic encephalopathy.
University of North Carolina, Chapel Hill16 enrolled2 locationsNCT06448780
Recruiting

Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders

Traumatic Brain Injury (TBI)Hypoxic-ischemic encephalopathy (HIE)Williams Syndrome+20 more
Healing Hope International100 enrolled1 locationNCT07493096
Recruiting
Phase 2

Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy

Neonatal EncephalopathyNeonatal AsphyxiaHypoxic-ischemic encephalopathy.
Pharmazz, Inc.40 enrolled4 locationsNCT05514340
Recruiting
Phase 2

A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures

Neonatal EncephalopathyNeonatal SeizureSeizure Newborn+1 more
University of California, San Diego133 enrolled5 locationsNCT05610085
Recruiting
Early Phase 1

Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

Hypoxic-ischemic encephalopathy.
University of Florida70 enrolled2 locationsNCT02621944
Recruiting
Not Applicable

The HIEnome Study: Genome Sequencing for Perinatal HIE

Hypoxic-ischemic encephalopathy (HIE)Hypoxic Ischemic Encephalopathy of NewbornHypoxic-ischemic encephalopathy.
Baylor College of Medicine25 enrolled2 locationsNCT06762795
Recruiting

Prognostic Factors to Regain Consciousness

Traumatic Brain InjuryStrokeNeurologic Disorder+2 more
BDH-Klinik Hessisch Oldendorf130 enrolled1 locationNCT04445649
Recruiting
Not Applicable

Spinal Stimulation and Mobility Devices

StrokeCerebral PalsyPremature Birth+2 more
University of Washington20 enrolled1 locationNCT05520359
Recruiting
Not Applicable

Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up

Birth asphyxiaHypoxic-ischemic encephalopathy.
Nemours Children's Clinic3,442 enrolled9 locationsNCT03682042
Recruiting
Not Applicable

Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit

Intraventricular hemorrhagePremature BirthBronchopulmonary Dysplasia+2 more
Shirley Ryan AbilityLab222 enrolled3 locationsNCT05568264
Recruiting

Healthy Little Eyes

Neonatal EncephalopathyEncephalopathyHypoxic-ischemic encephalopathy.
University of Wisconsin, Madison125 enrolled1 locationNCT05971446
Recruiting
Not Applicable

Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases

Short Bowel SyndromeBronchopulmonary DysplasiaHypoxic-ischemic encephalopathy.
Shandong Qilu Stem Cells Engineering Co., Ltd.120 enrolled1 locationNCT06427642
Recruiting

Systemic Biomarkers of Brain Injury From Hyperammonemia

Urea Cycle DisorderOrganic AcidemiaMaple Syrup Urine Disease+3 more
Children's National Research Institute24 enrolled1 locationNCT04602325