Applying pGz in Mitochondrial Disease

This study examines how a treatment called periodic gravitational stimulation (pGz) — a gentle rocking motion applied using a specialized table — affects exercise tolerance and muscle function in people with primary mitochondrial disease (PMD), a rare genetic condition that impairs the body's ability to produce energy. The study also includes healthy controls and hospitalized children with neuromuscular conditions for comparison. You may be eligible if (Aim 1 — outpatient): - You are between 10 and 60 years old and at least 135 cm tall - You can walk and perform routine exercise testing - You have a genetically confirmed mitochondrial myopathy (for patients) OR are a healthy volunteer You may be eligible if (Aim 2 — hospitalized): - You are between 10 and 23 years old - You are admitted to a PICU and expected to stay more than 24 hours - You have a genetically confirmed mitochondrial or neuromuscular disease, or no known genetic diagnosis You may NOT be eligible if: - You have a tracheostomy, severe heart or lung disease, or recent hospitalization within 1 month - You have vertigo, claustrophobia, or cognitive impairment - You are pregnant or breastfeeding - You have had a prior liver transplant, have portal vein thrombosis, or have cystic fibrosis - You have a known allergy to Lumason (the ultrasound contrast agent) - You have metal implants or history of injuries that cannot be cleared for MRI Talk to your doctor to see if this trial is right for you.