RecruitingNCT05573997

Novel Echocardiographic Biomarkers Assessing the Myocardial Work in Heart Failure

Clinical Value of Novel Echocardiographic Biomarkers Assessing the Myocardial Work in Heart Failure

Sponsor

Aristotle University Of Thessaloniki

Enrollment

300 participants

Start Date

Apr 10, 2022

Study Type

OBSERVATIONAL

Conditions

Heart Failure Cardiovascular Diseases Valvular Heart Disease Biochemical Dysfunction

Summary

This study seeks to investigate the clinical value of novel echocardiographic indices, including myocardial work parameters, during the acute phase of heart failure hospitalization. The trajectory of novel echocardiographic indices from the start to the end of hospitalization will be captured, as a means to unravel and subsequently better understand the diverse pathophysiology of different phenotypes of the heart failure continuum. Correlation between novel echocardiographic indices with clinical data, biochemical data, different heart failure phenotypes, and therapeutic maneuvers will be attempted. Prognostic implications of those indices will be explored.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced echocardiography (heart ultrasound) to measure new markers of how the heart muscle works in patients admitted to the hospital with heart failure. Researchers hope these new measurements will better predict patient outcomes than existing tests. **You may be eligible if...** - You have been admitted to the hospital with symptoms of heart failure - Your blood shows an elevated level of a heart stress marker (NT-proBNP) within 24 hours of admission - Your echocardiogram shows abnormal heart structure or function consistent with heart failure **You may NOT be eligible if...** - Your heart failure is caused by congenital heart disease, heart valve infection, pericardial disease, or recent heart surgery - You have other conditions that prevent reliable echocardiography measurements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTInvestigation of clinical profile, laboratory and novel echocardiographic imaging biomarkers

Complete and comprehensive medical interview will be conducted in each eligible patient. In addition, patient's laboratory data will be recorded on admission and pre-discharge. Each patient will undergo a full echocardiographic examination with a specific protocol upon admission and pre-discharge. This will include among others 2-dimensional speckle-tracking analysis of all cardiac chambers, and non-invasive calculation of myocardial work indices of the left and right ventricle.

Locations(1)

AHEPA University Hospital, Thessaloniki, Greece

Thessaloniki, Central Macedonia, Greece

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NCT05573997

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