RecruitingNCT05573997

Novel Echocardiographic Biomarkers Assessing the Myocardial Work in Heart Failure

Clinical Value of Novel Echocardiographic Biomarkers Assessing the Myocardial Work in Heart Failure

Sponsor

Aristotle University Of Thessaloniki

Enrollment

300 participants

Start Date

Apr 10, 2022

Study Type

OBSERVATIONAL

Conditions

Heart Failure Cardiovascular Diseases Valvular Heart Disease Biochemical Dysfunction

Summary

This study seeks to investigate the clinical value of novel echocardiographic indices, including myocardial work parameters, during the acute phase of heart failure hospitalization. The trajectory of novel echocardiographic indices from the start to the end of hospitalization will be captured, as a means to unravel and subsequently better understand the diverse pathophysiology of different phenotypes of the heart failure continuum. Correlation between novel echocardiographic indices with clinical data, biochemical data, different heart failure phenotypes, and therapeutic maneuvers will be attempted. Prognostic implications of those indices will be explored.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Patients acutely admitted at the Department of Cardiology of AHEPA University General Hospital, Thessaloniki, Greece with symptoms and/or signs of heart failure (HF), as those are defined by the European Society of Cardiology.
Patients with abnormal plasma concentration of N-terminal pro-B-type natriuretic peptide, measured within 24 hours from admission
Objective echocardiographic evidence of cardiac structural and/or functional abnormalities consistent with the presence of left ventricular (LV) systolic dysfunction/diastolic dysfunction/raised LV filling pressures upon admission assessment

Exclusion Criteria6

Symptoms and/or signs of HF secondary to congenital heart disease, infective endocarditis, pericardial disease, and history of recent cardiac surgery (\<1 month)
Patients receiving maintenance hemodialysis
Patients with active malignancy and/or life expectancy \< 1 year
Poor echocardiographic acoustic windows precluding reliable assessment and/or analysis
Heart transplantation
Patients not providing informed written consent to participate in the study

Interventions

DIAGNOSTIC_TESTInvestigation of clinical profile, laboratory and novel echocardiographic imaging biomarkers

Complete and comprehensive medical interview will be conducted in each eligible patient. In addition, patient's laboratory data will be recorded on admission and pre-discharge. Each patient will undergo a full echocardiographic examination with a specific protocol upon admission and pre-discharge. This will include among others 2-dimensional speckle-tracking analysis of all cardiac chambers, and non-invasive calculation of myocardial work indices of the left and right ventricle.