RecruitingNCT05574140

BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders

BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders (B-GLAD)


Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Enrollment

84 participants

Start Date

Jul 15, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how breathing patterns affect blood flow to the heart and brain in people with anxiety disorders, using MRI scans. The goal is to better understand the physical effects of anxiety on the body, which could inform new treatment approaches. **You may be eligible if...** - You are between 18 and 55 years old - You have been identified as having an anxiety disorder OR you are a healthy volunteer - You are a non-smoker with no significant heart, lung, or neurological conditions **You may NOT be eligible if...** - You have a pacemaker, metal implants, or other MRI contraindications - You are pregnant - You have a history of significant neurological disease (beyond anxiety) - You have a history of claustrophobia or difficulty in confined spaces Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTCardiac MRI

The 4-minute breathing maneuver comprised of 2 minutes of normal breathing and 1-min hyperventilation (rate of 30 breaths per minute) followed by a maximal breath-hold. This technique is used in Oxygenation Sensitive CMR, a type of MRI, and will induce a vasoactive response visible in cardiac and cerebral MRI images


Locations(1)

Emotional Health CBT Clinic

Montreal, Quebec, Canada

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NCT05574140


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