BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders
BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders (B-GLAD)
McGill University Health Centre/Research Institute of the McGill University Health Centre
84 participants
Jul 15, 2022
OBSERVATIONAL
Conditions
Summary
This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.
Eligibility
Inclusion Criteria9
- Patient population:
- Age 18-55,
- Confirmation of an anxiety disorder as identified by the PSWQ,
- No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system (except anxiety and depression)
- Non-smoker
- Healthy Volunteers:
- Age 18-55
- No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system
- Non-smoker
Exclusion Criteria9
- General MRI contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, pregnancy
- History of significant neurological disease or illness that is not anxiety (e.g. Dementia, stroke)
- Hemodynamically unstable conditions
- Significant or uncontrolled arrhythmias
- Severe pulmonary disease
- Recent (\<90 days) myocardial infarction
- Recent (\<90 days) surgery or coronary intervention
- Consumption of caffeine (caffeinated beverages, coffee, tea, cocoa, chocolate) within 12h of the exam
- Use of benzodiazepines or other short-acting anxiety medications (\<1 day)
Interventions
The 4-minute breathing maneuver comprised of 2 minutes of normal breathing and 1-min hyperventilation (rate of 30 breaths per minute) followed by a maximal breath-hold. This technique is used in Oxygenation Sensitive CMR, a type of MRI, and will induce a vasoactive response visible in cardiac and cerebral MRI images
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05574140