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RecruitingPhase 3NCT05576818

Effect of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease

Clinical Study Evaluating the Efficacy and Safety of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease

Sponsor

Tanta University

Enrollment

66 participants

Start Date

Jun 30, 2022

Study Type

INTERVENTIONAL

Conditions

Parkinson's Disease

Summary

This study aims to investigate the possible efficacy and safety of synbiotic preparation of Lactobacillus acidophilus probiotic with prebiotic fibers as an adjuvant therapy in the treatment of Parkinson's disease

Eligibility

Min Age: 45 YearsMax Age: 65 Years

Inclusion Criteria4

  • Age between 45 and 65 years old
  • Both sexes
  • Patients with Parkinson's disease on dopamine replacement therapy
  • Modified Hoehn and Yahr stage, MHY 1-4

Exclusion Criteria11

  • Patients who are currently using or used antibiotics therapy in the preceding month
  • Patients who are currently using or used other probiotic products in the preceding two weeks
  • Patients scheduled to undergo GIT surgery or those underwent GIT surgery
  • Patients with Known allergy to probiotics
  • Patients receiving artificial enteral or intravenous nutrition
  • Patients with depression and/or psychosis
  • Patients taking antioxidant and/or anti-inflammatory medications
  • Patients with Hyperthyroidism
  • Patients with inflammatory condition and/or condition involving oxidative stress
  • Smokers
  • Modified Hoehn \& Yahr stage MHY 5

Interventions

DRUGLactobacillus acidophilus 10 billion colony forming unit (CFU) and prebiotic fibers

Two sachets daily of synbiotic preparation containing Lactobacillus acidophilus 10 billion colony forming unit (CFU) and prebiotic fibers

Locations(1)

Tanta University

Tanta, El Gharbia, Egypt

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NCT05576818

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