RecruitingNCT05581147
Thyroid Function and Structure in Klinefelter Syndrome
Thyroid Function and Structure in Klinefelter Syndrome (THINKS)
Sponsor
University of Roma La Sapienza
Enrollment
600 participants
Start Date
May 11, 2007
Study Type
OBSERVATIONAL
Conditions
Summary
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
Eligibility
Sex: MALEMin Age: 1 YearMax Age: 80 Years
Inclusion Criteria3
- Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis;
- Availability of thyroid function test results (TSH, fT3, and fT4) and/or thyroid US imaging;
- Availability of concurrent clinical data.
Exclusion Criteria4
- Presence of other known genetic conditions or chromosomal abnormalities;
- Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests;
- History of previous surgery or radiotherapy on the thyroid or pituitary glands;
- Current or previous T therapy (for the pre-pubertal and pubertal groups).
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05581147
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