RecruitingNCT05589207

Predicting Model Based on Evidence-based Pathological Diagnose Criteria for RCC Tumor Thrombus With IVC Wall Invasion

Preoperative Imaging Diagnostic Evaluation Model Based on Evidence-based Pathological Diagnose Criteria for Renal Cell Carcinoma Tumor Thrombus With Inferior Vena Cava Wall Invasion


Sponsor

Peking University Third Hospital

Enrollment

232 participants

Start Date

Jan 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations, as well as a accurate and systematic pathological grading standard of inferior vena cava (IVC) vascular wall invasion in renal cell carcinoma (RCC) with tumor thrombus invading vascular wall.The main questions it aims to answer are: * To establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations. * To determine what impact does different vascular wall layer invasion make on the long-term prognosis in RCC with IVC tumor thrombus; * To determine which layer invasion according to pathological examination make sense to clinical treatment (can significantly affect prognosis); Participants with IVC vascular wall invasion/ non-invasion are divided into experimental group (invaded group) or control group (non-invaded group) respectively according to pathological examinations, in order to establish a prospective cohort with three-year follow-up. The pathological characteristics of local recurrence and poor prognosis are summarized, and postoperative pathological diagnostic criteria of IVC vascular wall invasion and established. The local recurrence and distant recurrence outcomes are compared between experiment group and control group, in order to analyze the long-term influence of vascular wall invasion. Then the preoperative imaging diagnostic evaluation model will be established.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is building a predictive model to better understand and treat kidney cancer (renal cell carcinoma) that has grown into the large vein (inferior vena cava) near the kidney. Researchers are collecting surgical and medical data to improve future surgical planning and outcomes. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with kidney cancer with a tumor that has grown into the vein (tumor thrombus) - You underwent surgery to remove the kidney and the tumor thrombus - You had standard imaging (ultrasound, CT, MRI) before surgery - You are willing to return for follow-up visits **You may NOT be eligible if...** - You did not undergo the standard surgery for any reason - You received treatment (chemotherapy, immunotherapy) before your surgery - You have a serious condition such as active tuberculosis or immune disease that may affect outcomes Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTVascular wall invaded

Inferior vena cava vascular wall is invaded according to pathologic examination on the postoperative tumor thrombus/ vascular wall specimen.


Locations(1)

Peking University Third Hospital

Beijing, Beijing Municipality, China

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NCT05589207


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