Sleep Disordered Breathing With Opioid Use
Targeting Chemoreceptor Control of Breathing During Sleep to Mitigate Opioid-Associated Sleep Disordered Breathing
VA Office of Research and Development
150 participants
May 2, 2019
INTERVENTIONAL
Conditions
Summary
There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.
Eligibility
Inclusion Criteria2
- Veterans, age 18-89 years
- Veterans with prescription opioids
Exclusion Criteria15
- Patients with BMI>40kg/m2 will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
- Patients with history of unresolved/untreated cardiac disease, including recent myocardial infarction, recent bypass surgery, untreated atrial and ventricular tachy-bradycardias
- Congestive heart failure with Cheyne-Stokes respiration (CSR)
- Current unstable angina
- Recent stroke
- Untreated schizophrenia
- Untreated hypothyroidism
- Unresolved seizure disorder
- Severe respiratory, neurological, liver and renal diseases
- Unstable psychiatric disorders/untreated PTSD
- Traumatic brain injury
- Pregnant women
- Significant sleep disorder such as narcolepsy, parasomnias disorder
- Failure to give informed consent
- Patients on tramadol and suboxone/buprenorphine
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Interventions
The ventilatory effects of brief hyperoxia will be assessed by analyzing control breaths on room air immediately preceding the hyperoxic exposure, and comparing with the primary end-point, nadir minute ventilation breath, immediately following the brief hyperoxic exposure.
Participants with sleep apnea will ingest capsules containing either placebo or acetazolamide 500 mg twice a day for 6 days. On the final 4 consecutive nights while still on ACZ, the investigators will perform i) physiology tests and ii) in-lab follow-up PSG.
Locations(1)
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NCT05589753