RecruitingPhase 1NCT05591027

Safety and Target Engagement of Centella Asiatica in Cognitive Impairment

Sponsor

Oregon Health and Science University

Enrollment

48 participants

Start Date

Dec 1, 2022

Study Type

INTERVENTIONAL

Conditions

Mild Cognitive Impairment

Summary

This clinical trial is focused on determining whether biological signatures of target engagement by a Centella asiatica water extract product administered orally for 6 weeks can be measured in comparison to placebo. This study will also assess the safety and tolerability of the Centella asiatica water extract product.

Eligibility

Min Age: 60 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the safety and brain effects of Centella asiatica — an herbal plant extract — in older adults who have mild cognitive impairment or are at risk for memory decline. Researchers want to see if it is safe and whether it reaches the right targets in the brain. **You may be eligible if...** - You are between 60 and 85 years old (male or female) - You have adequate vision and hearing to complete the tests - You have no known allergy to Centella asiatica - You do not have significant depression symptoms - Your BMI is between 17 and 35 **You may NOT be eligible if...** - You have conditions or are taking medications that would interfere with the study (as assessed by the study team) - You have significant depression or active suicidal thoughts Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCentella asiatica product

A sachet of powdered product containing 4 g of a dried hot water extract of Centella asiatica as the active ingredient, combined with inactive ingredients (excipients) for color and taste dissolved in 10 oz of warm or room temperature water and consumed orally.

DRUGPlacebo

A sachet of powdered inactive ingredients (excipients) for color and taste identical in volume to those found in the active arm (CAP) dissolved in 10 oz of warm or room temperature water and consumed orally.