Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)

This study is testing a focused re-irradiation approach (called ultra-hypofractionated partial breast re-irradiation) for women whose breast cancer has come back in the same breast after prior radiation. Rather than treating the whole breast again, this approach targets only the affected area with fewer, larger doses. **You may be eligible if...** - You are over 18 and have had a breast cancer recurrence (or a new primary tumor in the same breast) after prior radiation - The tumor is less than 3 cm and has been completely removed with clear margins - It has been more than 5 years since your previous radiation treatment - Your lymph nodes are not involved and there is no spread to other parts of the body **You may NOT be eligible if...** - Your cancer is present in multiple areas of the breast (multicentric disease) - You have lobular carcinoma only (a specific breast cancer subtype) - You have active serious medical conditions such as lupus or scleroderma - Your cancer has spread to lymph nodes or distant sites Talk to your doctor to see if this trial is right for you.