RecruitingEarly Phase 1NCT05593549

Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

Sponsor

Medical College of Wisconsin

Enrollment

60 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Type 2 Diabetes Healthy Aging

Summary

The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how a cell cleanup process called autophagy affects blood vessel function in people with type 2 diabetes. Understanding this may lead to better ways to prevent or treat complications like kidney disease, nerve damage, and eye problems in diabetes. **You may be eligible if...** - You are 18–80 years old - You have been diagnosed with type 2 diabetes (or you are a healthy person with no more than 1 cardiovascular risk factor, to serve as a comparison) **You may NOT be eligible if...** - You have uncontrolled high blood pressure - You currently smoke or have smoked in the last 6 months - Your BMI is above 35 - You have high cholesterol or triglycerides - You have type 1 diabetes, heart failure, kidney problems, or retinopathy - You take blood thinners or anti-platelet medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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