RecruitingEarly Phase 1NCT05597098

Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women

Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women: RESOLVE-SEX

Sponsor

Queen Mary University of London

Enrollment

34 participants

Start Date

Dec 12, 2022

Study Type

INTERVENTIONAL

Conditions

Inflammation

Summary

Important differences exist between sexes in incidence, disease patterns and outcomes in coronary artery disease that is not well understood. It is likely that key differences in the underlying biological mechanism, in particular in inflammatory responses, play a part in underpinning these differences. Previous evidence demonstrates that healthy females appear to be more adept at resolving inflammation compared to healthy males. Since inflammation is thought to be a key initiating phenomenon in coronary artery disease the investigators will examine the differences in inflammatory resolution between the sexes in healthy volunteers.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria3

Healthy male and female volunteers
Aged 18-45
Volunteers who are willing to sign the consent form

Exclusion Criteria7

Healthy subjects unwilling to consent
Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result
Current breast feeding
History of any serious illnesses, including recent infections or trauma
Subjects taking systemic medication (other than the oral contraceptive pill)
Subjects with recent (2 weeks) or current antibiotic use
Subjects with any history of a blood-borne infectious disease such as Hepatitis B or C virus, or HIV