RecruitingPhase 2NCT05597124

Exercise to Improve Brain Health in Older African Americans

Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer's Disease Risk in Older African Americans

Sponsor

Rutgers, The State University of New Jersey

Enrollment

280 participants

Start Date

Apr 20, 2023

Study Type

INTERVENTIONAL

Conditions

Cognitive Change Alzheimer Disease Aging Healthy Aging

Summary

The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question\[s\] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Balance (SFB) intervention on a cognitive marker of Alzheimer's risk, generalization? * What is the effect of the CDF vs. SFB intervention on a fMRI biomarker of Alzheimer's, neural flexibility, and do improvements in neural flexibility mediate improvements in generalization? * Do ABCA7 genotypic variations moderate the efficacy of the CDF vs. SFB intervention for reducing Alzheimer's risk? Participants will undergo-- at baseline and post-test-- health assessments, cognitive tests, and structural and functional magnetic resonance imaging (fMRI), and a blood-draw to assess Alzheimer's risk biomarker levels.

Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether regular exercise can improve brain health and reduce the risk of memory problems in older African American adults. Researchers believe exercise may help protect the brain as we age, and this trial focuses specifically on a group that is often underrepresented in research. **You may be eligible if...** - You self-identify as African American or Black - You are age 60 or older - You can speak, read, and understand English - You are able to walk without a wheelchair, walker, or cane - You are currently not very physically active **You may NOT be eligible if...** - You already exercise regularly - You have memory or cognitive problems that affect your daily life - You have a health condition that prevents you from exercising safely Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCardio-Dance Fitness

This is an aerobic cardio-dance fitness exercise class in a social context with aerobic intensity assessed by heart rate monitoring throughout the class. Participants will meet three times a week for approximately 60 minutes per session, over 24 weeks (approximately 6 months).

BEHAVIORALStrength, Flexibility & Balance

This intervention will serve as a stringent, structurally equivalent, active comparator to the CDF intervention, identical in duration, frequency, and social contact except for the content of this non-aerobic intervention. SFB will involve non-aerobic activity with strength, flexibility, and balance training.

Locations(1)

Rutgers, The State University of New Jersey - Newark campus

Newark, New Jersey, United States

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NCT05597124

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