RecruitingNCT05600634

Multi Center Observation of Sentinel Skin Graft for Detecting Acute Rejection After Renal Transplantation

Multi Center Clinical Observation of Sentinel Skin Graft From the Same Donor Source for Detecting Acute Rejection After Renal Transplantation

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Enrollment

24 participants

Start Date

Jan 1, 2024

Study Type

OBSERVATIONAL

Conditions

Kidney Transplant Rejection

Summary

The purpose of this study was to explore the accuracy of sentinel skin grafts from the same donor source in diagnosing renal allograft rejection, and to provide new ideas and options for the later clinical diagnosis of renal allograft rejection. Further, try to provide timing guidance for early immunization intervention.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria4

Patients with end-stage renal disease undergoing renal transplantation;
18-60 years old;
Postoperative follow-up points are complete (visit the hospital every week in the first month after surgery, every two weeks in 2-3 months, every four to six months, and every three months in 7-12 months. Follow up at any time when skin rejection is observed. The follow-up time may be adjusted when the condition changes);
The participants had good compliance, volunteered to participate in the test and signed the informed consent form.

Exclusion Criteria5

Untreated or disseminated malignant tumor;
Active period of infectious diseases;
Serious cardiovascular disease occurred recently;
Combined with other important organ failure;
History of mental illness or cognitive impairment;

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Interventions

PROCEDURESkin allotransplantation

Sentinel skin grafts from the same donor source will be carried on in the meantime of kidney transplantation for assisting to detect acute renal rejection.