RecruitingNCT05601856

Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers

Sponsor

University of Virginia

Enrollment

104 participants

Start Date

Dec 15, 2022

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Gut Biome

Summary

Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.

Eligibility

Min Age: 65 YearsMax Age: 90 Years

Inclusion Criteria4

patients with AD whose clinical dementia rating (CDR) is \> 1
Spouses of Patients in the above group Or
Healthy adult unrelated to groups 1 and 2, with no history of dementia And
Regardless of the grouping, the prospective subject must be between 65 and 90 years old

Exclusion Criteria15

Familial Alzheimer's Disease (AD)
Severe cardiovascular disease
Severe respiratory system disease
Severe liver disease
Severe kidney disease
Severe central nervous system diseases
Having a lifespan of fewer than 3 months
History of psychiatric illness
Major neurological diseases other than AD
Current use of corticosteroids, antibiotics, or bowel motility modification agents
Any history of Alcoholism or illicit drug dependence
Previous inclusion in this study
Difficulty with follow-up or poor compliance
Severe hearing impairment
Severe vision impairment