RecruitingPhase 2NCT05603715

Pyridostigmine for the Treatment of Constipation in Parkinson Disease

Sponsor

University of Vermont Medical Center

Enrollment

16 participants

Start Date

Aug 10, 2022

Study Type

INTERVENTIONAL

Conditions

Constipation Parkinson Disease

Summary

Constipation is a common and debilitating non-motor symptom of Parkinson disease (PD) that often precedes the onset of classic motor symptoms by decades. There is no standardized algorithm for managing constipation in this patient population, nor are there dedicated treatments. Studies suggest that constipation can affect quality of life to a significant degree, in many cases just as much as motor symptoms. There is an unmet need for effective treatment options for constipation in this patient population. The goal of this study is to determine the efficacy and safety of pyridostigmine as a treatment for chronic constipation in patients with PD.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether pyridostigmine, a drug typically used for a muscle weakness condition called myasthenia gravis, can also help relieve constipation in people with Parkinson's disease. Constipation is one of the most common and frustrating non-motor symptoms of Parkinson's, and researchers are exploring this drug as a potential solution. **You may be eligible if...** - You are 18 or older - You have Parkinson's disease - You experience chronic constipation as part of your condition - You are able to take oral medications - You are able to give informed consent and follow the study schedule **You may NOT be eligible if...** - You have conditions that make pyridostigmine unsafe, such as asthma, bowel obstruction, or urinary blockage - You are pregnant or sexually active without using effective contraception (for women of childbearing age) - You are already taking medications that interact with pyridostigmine Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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