Constipation Clinical Trials

97 recruitingLast updated: June 17, 2026

There are 97 actively recruiting constipation clinical trials across 30 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1. Top locations include Indianapolis, Indiana, United States, London, United Kingdom, Ann Arbor, Michigan, United States. Updated daily from ClinicalTrials.gov.


Constipation Trials at a Glance

97 actively recruiting trials for constipation are listed on ClinicalTrialsFinder across 6 cities in 30 countries. The largest study group is Not Applicable with 60 trials, with the heaviest enrollment activity in Indianapolis, London, and Ann Arbor. Lead sponsors running constipation studies include Wecare Probiotics Co., Ltd., Mayo Clinic, and Ardelyx.

Browse constipation trials by phase

Treatments under study

About Constipation Clinical Trials

Looking for clinical trials for Constipation? There are currently 55 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Constipation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Constipation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 97 trials

Recruiting
Not Applicable

Nutritional Intervention for Constipation Symptoms in Patients With Parkinson's Disease

Parkinsons Disease (PD)Constipation - Functional
Hospital de Clinicas de Porto Alegre54 enrolled1 locationNCT07213856
Recruiting
Not Applicable

Probiotic Improve Constipation

Constipation
Wecare Probiotics Co., Ltd.105 enrolled1 locationNCT07462481
Recruiting
Phase 3

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

Chronic Idiopathic Constipation (CIC)
Ardelyx692 enrolled109 locationsNCT07382167
Recruiting
Not Applicable

A Study of Herbal Supplements in Cancer Survivors With Constipation

CancerConstipationFunctional Constipation
Memorial Sloan Kettering Cancer Center70 enrolled7 locationsNCT07091084
Recruiting
Phase 2

4-Week, Multi-center Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrs

Irritable Bowel Syndrome With Constipation (IBS-C)
Ardelyx72 enrolled20 locationsNCT06553547
Recruiting
Not Applicable

Dose-Effect Response in Acupuncture for Functional Constipation

Functional Constipation (FC)
Tongji Hospital72 enrolled2 locationsNCT07506122
Recruiting
Phase 2

A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

ConstipationIrritable Bowel Syndrome
Eli Lilly and Company342 enrolled1 locationNCT07545772
Recruiting
Not Applicable

Randomized, Blinded, Placebo-Controlled Evaluation of BioAmicus Complete

ConstipationAtopic DermatitisInfantile Colics+1 more
NovoNatum Ltd140 enrolled1 locationNCT07444008
Recruiting
Not Applicable

Efficacy of LcS-Fermented Milk on Constipation-Related Symptoms in Filipino Adults

Gastrointestinal DiscomfortConstipation
University of Santo Tomas60 enrolled1 locationNCT07083596
Recruiting

A Study of Prucalopride in Breastfeeding Women With Constipation

Chronic Idiopathic Constipation (CIC)
Takeda12 enrolled1 locationNCT04838522
Recruiting
Phase 1Phase 2

Safety and Pharmacokinetics Study of Naldemedine in Paediatric Participants Receiving Opioids

Opioid-Induced Constipation (OIC)
Shionogi24 enrolled16 locationsNCT05588323
Recruiting
Phase 2Phase 3

Maralixibat in Patients With Cystic Fibrosis and Constipation

Cystic FibrosisConstipation Chronic Idiopathic
Children's Hospital Los Angeles20 enrolled1 locationNCT06413368
Recruiting
Not Applicable

Peristeen Light Explorative Clinical Investigation

Faecal IncontinenceConstipation - Functional
Coloplast A/S60 enrolled2 locationsNCT07126327
Recruiting
Not Applicable

Electro-acupuncture for Irritable Bowel Syndrome With Constipation

Irritable bowel syndrome with constipation
Nanyang Technological University60 enrolled1 locationNCT06219707
Recruiting
Not Applicable

Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables

Hirschsprung DiseaseConstipation - FunctionalGastrointestinal Motility Disorders in Children
Friedrich-Alexander-Universität Erlangen-Nürnberg25 enrolled1 locationNCT07519915
Recruiting
Not Applicable

Impact of the Inno Cleanse Dietary Supplement on Gut Health and Associated Variables in Healthy Men and Women

Constipationbloating
University of Memphis30 enrolled1 locationNCT07215351
Recruiting
Not Applicable

The Efficacy and Palatability of Developed Polyethylene Glycol-based Formula for Children With Functional Constipation

Functional Constipation
Chulalongkorn University52 enrolled1 locationNCT06357897
Recruiting
Not Applicable

Chronic Ingestion of Fructooligosaccharide and Psyllium on Intestinal Transit in Women With Functional Constipation: A Randomized Crossover Trial

Constipation - Functional
Federal University of Minas Gerais25 enrolled1 locationNCT07202481
Recruiting
Phase 3

Assessing Tenapanor as a Treatment of CF-related Constipation.

ConstipationCystic Fibrosis
Massachusetts General Hospital25 enrolled1 locationNCT06810167
Recruiting
Not Applicable

Optimization of Postoperative Bowel Habits

Constipation
Wake Forest University Health Sciences88 enrolled1 locationNCT06335797