RecruitingPhase 1NCT05610878

Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting

Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities


Sponsor

University of the Punjab

Enrollment

24 participants

Start Date

Nov 20, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether fat grafting (transferring fat from one part of the body to another for cosmetic or reconstructive purposes) works better when the transferred fat cells are enriched with specially preconditioned stem cells. Researchers hope this approach will improve how well the grafted fat survives and looks long-term. You may be eligible if: - You are between 18 and 50 years old - Your BMI is between 20 and 30 kg/m² - You are a suitable candidate for liposuction based on expected cosmetic results - You have provided signed informed consent You may NOT be eligible if: - You have a systemic disorder such as an autoimmune disease, bleeding disorder, bone marrow condition, cancer, or active infection - You have a local skin condition such as acne or active skin infection at the treatment area - You are a smoker - You have uncontrolled diabetes or hypertension - You have an allergy to general anaesthesia medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCultured ASCs enrichment fat grafting

Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs and grafted into recipient site with 1,00,000 cells/ml injected fat

BIOLOGICALCurcumin-preconditioned ASCs enrichment fat grafting

Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs preconditioned with curcumin and grafted into recipient site with 1,00,000 cells/ml injected fat

OTHERConventional fat grafting

Patients will undergo conventional fat harvesting and grafting of fat into recipient site


Locations(1)

Stem Cell Laboratory, Jinnah Burn and Reconstructive Surgery Center (JB&RSC)

Lahore, Punjab Province, Pakistan

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NCT05610878


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