Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities
University of the Punjab
24 participants
Nov 20, 2020
INTERVENTIONAL
Conditions
Summary
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.
Eligibility
Inclusion Criteria4
- Age 18-50 years (male or female)
- Body-mass index 20-30 kg/m²
- Suitable for liposuction as assessed by the expected cosmetic results
- Provided signed informed consent
Exclusion Criteria4
- Systemic disorders include autoimmune diseases, hemorrhagic diseases, bone marrow aplasia, sepsis, cancer, and others
- Local disorders include acne, infections and others
- Risk factors include smoking, uncompensated diabetes, hypertension, and allergy to the drugs used for general anesthesia
- Microbiological contamination of either the cell culture or the transplanted tissue
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Interventions
Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs and grafted into recipient site with 1,00,000 cells/ml injected fat
Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs preconditioned with curcumin and grafted into recipient site with 1,00,000 cells/ml injected fat
Patients will undergo conventional fat harvesting and grafting of fat into recipient site
Locations(1)
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NCT05610878