A Study of Tooth Erosion in People With Esophagogastric Cancer
Pilot Study of Dental Erosion as a Non-invasive Biomarker of Esophagogastric Cancer
Memorial Sloan Kettering Cancer Center
300 participants
Nov 3, 2022
INTERVENTIONAL
Conditions
Summary
The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.
Eligibility
Inclusion Criteria5
- Subject is willing and able to provide written informed consent.
- Patients with a history of esophagogastric, HNSCC, PDAC, CRC, or NSCLC or healthy controls
- Patients must be able to fully comprehend and complete the survey and be willing to have pictures taken of their teeth with a camera or intra-oral camera.
- Patients must be able to understand English language or have access to adequate translation services.
- Age ≥ 18 years old.
Exclusion Criteria2
- Subjects without evaluable molars or with significant molar dental work precluding dentists from assessing enamel status, Note: evaluable is defined as having bilateral assessable mandibular molars, or erosions present in the remaining assessable quadrants.
- For healthy controls only, patients cannot have a non-skin cancer history nor presenting for a procedure evaluating reflux symptoms.
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Interventions
This is a 15-item questionnaire. The questionnaire asks subjects to quantify, during a specified duration of time, the number of times they have consumed or completed a task (ex. alcohol intake, cigarette use, and teeth brushing frequency). Additionally, the questionnaire further asks subjects to quantify their GERD symptoms and risk factors prior to diagnosis. All study procedures will be completed in one visit as part of a standard-of-care clinic visit.
Intraoral pictures of molars and incisors in 13 key regions
Cohort 1 only. Participant is responsible for collecting and bringing the salvia sample to clinic.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05612048