RecruitingNot ApplicableNCT05612048

A Study of Tooth Erosion in People With Esophagogastric Cancer

Pilot Study of Dental Erosion as a Non-invasive Biomarker of Esophagogastric Cancer

Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

300 participants

Start Date

Nov 3, 2022

Study Type

INTERVENTIONAL

Conditions

Esophagogastric Cancer

Summary

The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether people with certain cancers — especially esophageal, gastric, head and neck, pancreatic, colorectal, or lung cancer — show more tooth erosion compared to healthy individuals, and whether this could serve as a visible health indicator. **You may be eligible if...** - You are 18 years or older - You have a history of esophagogastric cancer, head and neck squamous cell carcinoma (HNSCC), pancreatic cancer, colorectal cancer, or non-small cell lung cancer — OR you are a healthy control - You can understand English or have access to a translator - You consent to photos being taken of your teeth **You may NOT be eligible if...** - You do not have evaluable back teeth (molars), or significant dental work on your back teeth that would prevent assessment of tooth enamel Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERSurvey

This is a 15-item questionnaire. The questionnaire asks subjects to quantify, during a specified duration of time, the number of times they have consumed or completed a task (ex. alcohol intake, cigarette use, and teeth brushing frequency). Additionally, the questionnaire further asks subjects to quantify their GERD symptoms and risk factors prior to diagnosis. All study procedures will be completed in one visit as part of a standard-of-care clinic visit.

OTHERIntra-oral camera

Intraoral pictures of molars and incisors in 13 key regions

OTHEROptional Salvia sample

Cohort 1 only. Participant is responsible for collecting and bringing the salvia sample to clinic.

Locations(1)

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05612048

Related Trials

PET-MRI Esophagus Feasibility Study

NCT057961021 location

Folfox+Irinotecan+Chemort In Esophageal Cancer

NCT046560413 locations