PET-MRI Esophagus Feasibility Study
Feasibility Study of PET-MRI as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Esophagogastric Cancer
University Health Network, Toronto
15 participants
Mar 28, 2023
INTERVENTIONAL
Conditions
Summary
This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided. The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.
Eligibility
Inclusion Criteria3
- Patients 18 years or older
- Diagnosed with locally advanced esophageal cancer being considered for conventional RT >4 weeks
- Ability and willingness to provide written informed consent
Exclusion Criteria5
- Contraindication for MRI
- Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes)
- Any patient who is pregnant or breastfeeding
- Pacemaker or implanted defibrillator
- Claustrophobia
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Interventions
A PET/MRI scan is a two-in-one test that combines images from a positron emission tomography (PET) scan and a magnetic resonance imaging (MRI) scan. Magnetic Resonance Imaging (MRI) provides better soft tissue contrast compared to conventional computerized tomography (CT), and when combined with PET, can potentially provide better visualization of the tumor shape, size, and position. Additional MRI imaging will be completed once during radiation treatment, and once after radiation treatment
Locations(1)
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NCT05796102