RecruitingNot ApplicableNCT05617495

Mindfulness-Based fMRI Neurofeedback for Depression

Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)

Sponsor

Columbia University

Enrollment

90 participants

Start Date

Apr 10, 2024

Study Type

INTERVENTIONAL

Conditions

Rumination Depression in Adolescence

Summary

In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.

Eligibility

Min Age: 13 YearsMax Age: 18 Years

Inclusion Criteria5

Ages 13-18 years-old
Written informed assent/consent and parental/guardian permission for 13-17 year-olds or informed consent for 18 year-olds
Tanner puberty stage ≥3
Meets current diagnostic criteria for MDD
English fluency

Exclusion Criteria8

Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders
Substance use disorder, moderate or severe in past 6 months
Active suicidal ideation with a specific plan
History of seizure disorder
Medical or neurological illness (e.g., severe head injury)
MRI contraindications
Current psychotropic medication use other than antidepressant medication
Intelligence quotient (IQ) \<80.

Interventions

OTHERMindfulness + fMRI Neurofeedback

Prior to neurofeedback, participants will receive 45 minutes of mindfulness training. Participants will then receive mindfulness-based fMRI neurofeedback targeting the default mode network and frontoparietal control network.