RecruitingNot ApplicableNCT05617495

Mindfulness-Based fMRI Neurofeedback for Depression

Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)

Sponsor

Columbia University

Enrollment

90 participants

Start Date

Apr 10, 2024

Study Type

INTERVENTIONAL

Conditions

Rumination Depression in Adolescence

Summary

In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.

Eligibility

Min Age: 13 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a mindfulness-based brain training technique called neurofeedback — where teenagers view real-time images of their own brain activity during an MRI scan — as a new way to treat depression in adolescents. **You may be eligible if...** - You are 13–18 years old and have been diagnosed with major depressive disorder (clinical depression) - You are fluent in English - You have reached at least puberty stage 3 (assessed by a doctor) - A parent or guardian can provide consent for you if you are under 18 **You may NOT be eligible if...** - You have a history of psychosis, bipolar disorder, autism, PTSD, or an eating disorder - You have a moderate or severe substance use problem in the past 6 months - You have active suicidal thoughts with a specific plan - You have a seizure disorder, significant brain injury, or other major medical or neurological illness - You cannot have an MRI (e.g., metal implants) - You are currently on psychiatric medications other than antidepressants - Your estimated IQ is below 80 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMindfulness + fMRI Neurofeedback

Prior to neurofeedback, participants will receive 45 minutes of mindfulness training. Participants will then receive mindfulness-based fMRI neurofeedback targeting the default mode network and frontoparietal control network.