RecruitingNot ApplicableNCT05691439

Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function

Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function


Sponsor

University of Oregon

Enrollment

150 participants

Start Date

Mar 27, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This research will use biobehavioral approaches to generate understanding about the linkages between sleep duration and timing, stressful life events, and depressive symptoms in adolescents, with a long-term aim of developing effective preventative interventions.


Eligibility

Min Age: 14 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates the connection between sleep patterns and depression in teenagers, using brain imaging to understand how poor sleep affects mood and the brain's reward and stress systems in adolescents. **You may be eligible if...** - You are between 14 and 18 years old and currently in high school - You either sleep short hours and go to bed late on school nights (short/late sleep group), OR sleep longer hours and go to bed earlier (long/early sleep group) - You have experienced at least 2 stressful life events (based on a screening questionnaire) - You have at least mild depressive symptoms on a standard questionnaire - You are fluent in English **You may NOT be eligible if...** - You have a moderate to severe alcohol or substance use disorder - You have been diagnosed with narcolepsy, bipolar disorder, or schizophrenia - You have a serious medical condition like heart failure or a history of head injury with prolonged unconsciousness - You cannot have an MRI (e.g., metal implants in your body) - You have epilepsy or eye disease that makes bright light exposure unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALSleep extension and advance

Participants in the sleep extension and advance condition will maintain a stable sleep schedule that extends sleep duration and advances bedtime by 90 min relative to weekday bedtime. This chronotherapeutic manipulation will include blocking phase-delaying light in the evening using goggles with orange lenses ("blue blockers") beginning 2 h prior to bedtime, and 30 min of 506 lux blue-green light exposure in the morning beginning at rise time using bright light goggles (ReTimer Pty Ltd., Australia). Schedule and chronotherapy adherence will be reinforced using motivational techniques (e.g., securing motivation, preplanning, problem-solving), requiring participants to text the study coordinator and complete morning assessments at rise time, and monetary incentives.

BEHAVIORALRegular sleep duration and timing

Participants in the regular sleep duration and timing condition will keep a stable sleep schedule that matches their typical weekday sleep opportunity and timing. Schedule adherence will be reinforced using motivational techniques (e.g., securing motivation, preplanning, problem-solving), requiring participants to text the study coordinator and complete morning assessments at rise time, and monetary incentives.


Locations(1)

University of Oregon

Eugene, Oregon, United States

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NCT05691439


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