RecruitingNot ApplicableNCT05617898

Determining the Role of Social Reward Learning in Social Anhedonia

Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach

Sponsor

University of Alabama at Birmingham

Enrollment

152 participants

Start Date

Jun 14, 2023

Study Type

INTERVENTIONAL

Conditions

Psychosis

Summary

This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.

Eligibility

Min Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating why some people with schizophrenia or related conditions lose interest in social interactions — a symptom called social anhedonia — by studying how the brain learns from social rewards using brain scans. **You may be eligible if...** - You are 18–35 years old - You have had a first episode of a psychotic illness (such as schizophrenia or schizoaffective disorder) within the past three years - You have a DSM-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder - You are currently taking a second-generation antipsychotic medication - You are fluent in English and have corrected vision of at least 20/30 - You are eligible for MRI scanning (no metal implants or pacemaker) **You may NOT be eligible if...** - Substance use explains your psychotic symptoms - You have had a moderate or severe alcohol or drug use disorder in the past 3 months - You have a significant medical or neurological illness - You are pregnant - You have recently changed your medication (within 3 weeks) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMotivational Interviewing

Three motivational interviewing sessions will target sensitivity to social reward, including subjective evaluation of social interaction, socially rewarding stimuli, and events (e.g., interactions with others, feedback from others).

BEHAVIORALNutrition Didactic Training

The Nutrition didactic training will ask participants to discuss pros and cons of healthy eating habits and how to improve their current eating habits.