RecruitingNot ApplicableNCT05617898

Determining the Role of Social Reward Learning in Social Anhedonia

Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach

Sponsor

University of Alabama at Birmingham

Enrollment

152 participants

Start Date

Jun 14, 2023

Study Type

INTERVENTIONAL

Conditions

Psychosis

Summary

This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.

Eligibility

Min Age: 18 YearsMax Age: 35 Years

Inclusion Criteria8

Age 18-35 years
A first episode of a psychotic illness that began within the past three years
Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
Taking 2nd generation antipsychotic medications
Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading
Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning
Sufficient fluency in English to comprehend testing procedures
Corrected vision of at least 20/30

Exclusion Criteria6

No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)
No evidence of moderate or severe alcohol or substance use disorder in the past 3 months
No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury
For females: no current pregnancy
No sedatives or anxiolytics on the day of assessment
No medication change 3 weeks prior to enrollment

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Interventions

BEHAVIORALMotivational Interviewing

Three motivational interviewing sessions will target sensitivity to social reward, including subjective evaluation of social interaction, socially rewarding stimuli, and events (e.g., interactions with others, feedback from others).

BEHAVIORALNutrition Didactic Training

The Nutrition didactic training will ask participants to discuss pros and cons of healthy eating habits and how to improve their current eating habits.