RecruitingNot ApplicableNCT05620680

CD7 CAR-T Cells in T-cell Lymphoma/Leukemia

Study of CD7 CAR-T Cells in Adult Refractory and Recurrent T-cell Lymphoma/Leukemia


Sponsor

Shenzhen University General Hospital

Enrollment

20 participants

Start Date

Oct 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

T-cell lymphoma/leukemia is a group of highly lethal diseases with a high relapse rate and poor prognosis. CD7 was proved to be widely expressed in T-cell malignant, which makes it a promising therapeutic target. In this study we aim to test the safety and efficacy of CD7 CAR-T cells in T-cell lymphoma/leukemia.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing CAR-T cell therapy using cells engineered to target a protein called CD7, found on T-cell lymphoma and leukemia cells, in people whose cancer has come back or stopped responding to standard treatments. **You may be eligible if...** - You are between 18 and 75 years old with confirmed relapsed or refractory T-cell lymphoma or leukemia - Your cancer has failed initial treatment or relapsed after achieving remission - Your general health score is 0–2 and expected survival is more than 3 months - You have no contraindications to the blood cell collection procedure - You have not received antibody therapy in the 2 weeks before cell therapy **You may NOT be eligible if...** - You are allergic to any component of the cell product - Your liver function, kidney function, or platelet count is below the required threshold - You have severe heart failure (Class III or IV) - Your blood oxygen level or lung function is significantly impaired Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCD7 CAR-T cells

patient was subjected to 0.5-2×10\^6 cells/kg of CD7 CAR- T


Locations(1)

Li Yu

Shenzhen, Guangdong, China

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NCT05620680


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