A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder
Auburn University
90 participants
Oct 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical study is to test the effectiveness of a supplemental fMRI neurofeedback and/or TMS intervention in individuals seeking treatment for Alcohol Use Disorder. After an initial visit, participants will come in once a week for four (4) weeks for an intervention session, which may or may not include TMS and MRI. Participants will be contacted for monthly follow-ups (remotely) for up to 12 months and will be asked to come in for two MRI follow-ups at 6 and 12 months.
Eligibility
Inclusion Criteria2
- Age 19-65
- Receiving treatment for Alcohol Use Disorder
Exclusion Criteria12
- MRI Contraindications
- Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos)
- Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr
- Hearing loss, including tinnitus, that might be made worse by MRI or TMS
- TMS Contraindications
- Has ever had a seizure, or has a family history of epilepsy
- Taking medications or substances that lower the seizure threshold
- Implanted devices that are in the head or rely on physiological signals
- History of neurological disease, such as stroke or brain tumor
- Head injury with loss of consciousness greater than 30 minutes
- Actively withdrawing from alcohol
- Family history of schizophrenia or presence of psychotic symptoms
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Interventions
fMRI aided reinforcement of craving regulation
rTMS to right dorsolateral prefrontal cortex to reduce craving
Display of feedback from other participant's sessions to serve as a sham for fMRI aided reinforcement of craving regulation
rTMS using placebo coil (no brain stimulation, emulates other features of active TMS), placed over right dorsolateral prefrontal cortex
Locations(1)
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NCT05621538