The Clinical Efficacy of Immunomodulators in RA Patients

Inclusion Criteria31

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• Patients with RA who meet ACR 1987 rheumatoid arthritis classification criteria or ACR/EULAR 2010 rheumatoid arthritis Classification Criteria and have knee dysfunction.
• ACR 1987 rheumatoid arthritis classification criteria
• morning stiffness lasting at least 1 hour (≥6w)
• there are 3 or more joint areas swollen (≥6w)
• swelling of the wrist, metacarpophalangeal, and proximal phalangeal joint areas (≥6w)
• symmetrical arthrogryposis (≥6w)
• hand x-ray changes (at least osteoporosis and joint space narrowing)
• positive rheumatoid factor (titer \> 1:32) RA can be diagnosed by meeting 4 of the above 7 items
• ACR/EULAR 2010 rheumatoid arthritis Classification Criteria
• Involved joints
• \- 1 large joint (0 points)
• large joints (1 point)
• small joints (with or without large joints) (2 points)
• small joints (with or without large joints) (3 points)
• more than 10 small joints (at least one small joint) (5 points)
• Serological indicators
• RF and ACPA negative (0 points)
• RF and ACPA, at least one of which is low titer positive. (2 points)
• RF and ACPA with at least one high titer positive (3 points)
• Acute chronotropic reactants
• Both CRP and ESR normal (0 points)
• Abnormal CRP or ESR (1 point)
• Duration of synovitis
• \<6 weeks (0 points)
• ≥6 weeks (1 point)
• Patients with OA who meet the 1995 Classification Criteria for OA and have knee dysfunction 1995 Classification Criteria for Osteoarthritis of the Knee Clinical criteria
• a. Knee pain most of the time in the last 1 month b. Bone rubbing sound c, morning stiffness ≤ 30 minutes d, age ≥ 38 years e, with bony enlargement Knee OA can be diagnosed if a+b+c+d or a+b+e is met
• Age-sex matched healthy volunteers who checked in our hospital.
• Age \> 18 years old;
• Voluntarily participate in this study and sign an informed consent form