Trauma Resuscitation With Low-Titer Group O Whole Blood or Products

This large randomized trial compares two approaches to blood transfusion for trauma patients who are bleeding severely: transfusing whole blood (low-titer group O whole blood, LTOWB) versus the standard approach of giving separate components (packed red blood cells and plasma). The goal is to find out which method leads to better survival and outcomes after major traumatic injury. You may be eligible if... - You are an adult trauma patient (or over 15 years old, or over 50 kg) - You were brought directly to a trauma center from the scene of injury - You required blood transfusion and triggered the massive hemorrhage/transfusion protocol - You have confirmed or suspected major bleeding from trauma You may NOT be eligible if... - You were transferred from another hospital - You are under 15 years old - You have severe burns (over 20% body surface area) - You are obviously pregnant - You have a "do not resuscitate" order - You are expected to die within 1 hour - You refuse blood products - You have already received more than 2 units of whole blood or the equivalent in components before enrollment Talk to your doctor to see if this trial is right for you.