RecruitingPhase 3NCT05638581

Trauma Resuscitation With Low-Titer Group O Whole Blood or Products

Sponsor

University of Alabama at Birmingham

Enrollment

1,100 participants

Start Date

Jul 27, 2023

Study Type

INTERVENTIONAL

Conditions

Wounds and Injuries Shock, Hemorrhagic

Summary

The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and cryoprecipitate) in critically injured patients who require large-volume blood transfusions.

Eligibility

Min Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called Components and a biological treatment called LTOWB for people with shock, hemorrhagic and wounds and injuries. The study is currently recruiting participants at 13 locations. People eligible for this study include aged 15 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALLTOWB

Participants will receive Low Titer O Whole Blood administered intravenously or intraosseously.

BIOLOGICALComponents

Participants will receive separated blood components (i.e., units of red cells, plasma, platelets, and cryoprecipitate) co-administered intravenously or intraosseously.

Locations(13)

University of Alabama at Birmingham, UAB Hospital

Birmingham, Alabama, United States

Los Angeles County + University of Southern California (LAC + USC) Medical Center

Los Angeles, California, United States

University Medical Center New Orleans LCMC Health

New Orleans, Louisiana, United States

University of Maryland Medical Center

Baltimore, Maryland, United States

Washington University School of Medicine

St Louis, Missouri, United States

Atrium Health Wake Forest Baptist

Winston-Salem, North Carolina, United States

University of Cincinnati Medical Center

Cincinnati, Ohio, United States

Oregon Health and Sciences University Hospital

Portland, Oregon, United States

Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, United States

University of Texas Health Science Center Houston

Houston, Texas, United States

University of Texas Health San Antonio and University Health System

San Antonio, Texas, United States

Harborview Medical Center

Seattle, Washington, United States

Froedtert Hospital

Milwaukee, Wisconsin, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05638581

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