RecruitingNCT05640700

Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia

Assessing Personalized Vaginal Microbiome Contributions to HPV-driven Pre-malignant and Malignant Cervical Cancer

Sponsor

Hadassah Medical Organization

Enrollment

90 participants

Start Date

Nov 9, 2022

Study Type

OBSERVATIONAL

Conditions

Human Papilloma Virus Cervical Dysplasia Vaginal Flora Imbalance Cancer Cervix Uterus

Summary

In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to construct a large dataset from patients with pre-cancerous cervical lesions and healthy women, to evaluate the personalized contribution of the vaginal microbiome to the CIN-CC sequence.

Eligibility

Sex: FEMALEMin Age: 25 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting vaginal swab samples from women attending a clinic for a Pap smear or colposcopy to investigate whether the bacteria naturally living in the vagina (the vaginal microbiome) are linked to HPV infection and abnormal cervical cell changes (cervical dysplasia). **You may be eligible if...** - You are between 25 and 70 years old - You are attending a clinic for a Pap smear or colposcopy appointment - You agree to provide a vaginal sample **You may NOT be eligible if...** - You have taken antibiotics in the past month - You have used any vaginal product (such as antifungal cream, spermicide, or lubricant) in the week before your visit - You are currently menstruating - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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