RecruitingNot ApplicableNCT05642156

Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis

Sponsor

Medical University of Graz

Enrollment

32 participants

Start Date

Nov 2, 2022

Study Type

INTERVENTIONAL

Conditions

End-stage Kidney Disease

Summary

Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two dialysis approaches in people with kidney failure who gain a lot of fluid between their shorter dialysis sessions: conventional hemodialysis versus isolated ultrafiltration (a method that removes only excess fluid without also cleaning the blood). The goal is to see which approach is better for blood pressure and heart function. **You may be eligible if...** - You are 18 or older with end-stage kidney disease on hemodialysis - Your weight has been stable for at least one month - You gain more than 2 liters of fluid between your shorter dialysis sessions **You may NOT be eligible if...** - You have a pacemaker or implanted device that conflicts with the study - You are already receiving a different type of dialysis (hemodiafiltration or certain membrane types) - You have severely high potassium levels requiring extended dialysis sessions - You are pregnant or of childbearing potential without acceptable contraception Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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