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RecruitingNot ApplicableNCT05646485

Bladder Cancer Screening Trial

Optimal Screening Strategy for Bladder Cancer in at Risk Patients

Sponsor

University of Texas Southwestern Medical Center

Enrollment

1,000 participants

Start Date

May 5, 2023

Study Type

INTERVENTIONAL

Conditions

Urothelial CarcinomaBladder CancerSmoking CessationHematuria

Summary

There is currently no accepted screening strategy for patients at high risk of developing bladder cancer. This study will ask patients to complete a urine test every 6 months for 2 years to help assess if routine screening helps finding bladder cancer at an earlier stage.

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new urine-based screening test to detect bladder cancer early in people who are at higher risk — particularly heavy smokers and people who have worked in certain industries for many years. **You may be eligible if...** - You are 50 years old or older - You have smoked at least 15 pack-years (e.g., 1 pack a day for 15 years) - OR you have worked for 15+ years in textile, painting, or dry cleaning industries **You may NOT be eligible if...** - You have had bladder, kidney, or prostate cancer in the past - You have already been evaluated for blood in your urine Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTUrinalysis

Urine analysis (every 6 months for 2 years); Patients with \<3 red blood cells (RBCs) per high-powered field (HPF) will repeat screening at 6-month intervals for an average of 2 years. If RBCs are 3-25 RBSc/HPF- subjects will undergo- \[cystoscopy + Upper tract imaging\] or \[urine marker cancer testing with Cxbladder triage + Upper tract imaging\]. If \>25 RBCs, subjects will get - \[cystoscopy + Upper tract imaging\].

Locations(1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States

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NCT05646485

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