Bladder Cancer Screening Trial
Optimal Screening Strategy for Bladder Cancer in at Risk Patients
University of Texas Southwestern Medical Center
1,000 participants
May 5, 2023
INTERVENTIONAL
Conditions
Summary
There is currently no accepted screening strategy for patients at high risk of developing bladder cancer. This study will ask patients to complete a urine test every 6 months for 2 years to help assess if routine screening helps finding bladder cancer at an earlier stage.
Eligibility
Inclusion Criteria3
- Age ≥ 50
- Smoking: ≥15 pack-year smoking history
- Occupation:≥ 15 years of occupational exposures including: textile worker, painter, dry cleaners
Exclusion Criteria3
- Prior history of bladder, kidney, or prostate cancer
- Prior evaluation of micro or gross hematuria within the last 2 years
- Do not provide informed consent
Interventions
Urine analysis (every 6 months for 2 years); Patients with \<3 red blood cells (RBCs) per high-powered field (HPF) will repeat screening at 6-month intervals for an average of 2 years. If RBCs are 3-25 RBSc/HPF- subjects will undergo- \[cystoscopy + Upper tract imaging\] or \[urine marker cancer testing with Cxbladder triage + Upper tract imaging\]. If \>25 RBCs, subjects will get - \[cystoscopy + Upper tract imaging\].
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05646485