RecruitingNCT05647109

Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer

Department of Obstetrics & Gynecology ，Peking University People's Hospital

Sponsor

Peking University People's Hospital

Enrollment

244 participants

Start Date

Sep 1, 2021

Study Type

OBSERVATIONAL

Conditions

To construct a prediction model of progesterone sensitivity in patients with endometrial cancer treated with fertility preservation

Sex: FEMALEMin Age: 17 YearsMax Age: 45 Years

Have a confirmed pathological diagnosis based upon hysteroscopy: atypical endometrial hyperplasia or histologically prove well-differentiated EEC G1 without myometrial invasion
No signs of suspicious extrauterine involvement on enhanced magnetic resonance imaging (MRI) or enhanced computed tomography (CT) or ultrasound
Have a desire for remaining reproductive function or uterus
Good compliance with adjunctive treatment and follow-up

Acute liver disease or liver tumor (benign or malignant) or renal dysfunction
Pregnancy or potential pregnancy
Confirmed diagnosis of any cancer in reproductive system
Acute severe disease such as stroke or heart infarction or a history of thrombosis disease
Hypersensitivity or contradiction for using MPA or MA
With other factors of reproductive dysfunction;
Strong request for uterine removal or other conservative treatment