Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer

This study uses tiny clusters of cells taken from a patient's own uterus to test whether that person's cancer is likely to respond to progesterone treatment — a hormone-based therapy that can preserve fertility. It helps doctors personalize treatment for women with early uterine cancer who want to avoid surgery. **You may be eligible if...** - You have been diagnosed with atypical endometrial hyperplasia or well-differentiated early-stage uterine cancer (Grade 1) - Your cancer has not spread to the uterine wall or beyond (confirmed by MRI) - You have not yet had a hysterectomy **You may NOT be eligible if...** - There are signs the cancer has spread outside the uterus - You have had prior treatment for uterine cancer - You have other serious medical conditions Talk to your doctor to see if this trial is right for you.