RecruitingNCT05649865

Monitoring and Early Response Evaluation Using HPV DNA - A Study on Patients With HPV-positive Throat Cancer (MER-HPV)

Analysis of HPV DNA in Plasma in Patients With HPV-positive Oropharyngeal Squamous Cell Carcinoma - a Prospective Study of HPV DNA Levels for Treatment Response and Surveillance

Sponsor

Region Skane

Enrollment

150 participants

Start Date

May 15, 2023

Study Type

OBSERVATIONAL

Conditions

Oropharynx Squamous Cell Carcinoma

Summary

The goal of this clinical trial is to determine the value of circulating tumour HPV DNA (human papilloma virus DNA found in the blood) at diagnosis, during treatment, and in the follow-up of patients diagnosed and treated for throat cancer caused by HPV. The main question to answer is if the presence of HPV DNA in the blood one month after the treatment is useful in detecting remaining tumour or relapse within two years after treatment. The participants will be asked to provide blood tests: 1. before treatment 2. weekly during the treatment 3. on all scheduled follow-up appointments 4. on all unplanned appointments where a relapse is suspected

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study monitors patients with HPV-related throat cancer using a simple blood test that detects HPV DNA in the bloodstream. The goal is to see if this test can track how well treatment is working and catch any cancer recurrence early. **You may be eligible if...** - You have been diagnosed with HPV-positive throat (oropharyngeal) cancer - You are 18 or older and being treated with curative intent - You are able to give informed consent **You may NOT be eligible if...** - Your cancer is not HPV-positive - You are not being treated for cure (e.g., palliative care only) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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