Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma

This study tests whether an 'adaptive therapy' approach — giving the cancer drug vismodegib in smaller, intermittent doses rather than continuously — can treat locally advanced basal cell carcinoma (a type of skin cancer) more effectively with fewer side effects. **You may be eligible if...** - You are 18 or older with locally advanced basal cell carcinoma confirmed by biopsy or cell analysis - Your cancer is not suitable for surgery or radiation, or those treatments have failed **You may NOT be eligible if...** - You have had prior treatment with vismodegib or a similar drug - Your cancer has spread to distant organs - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.