RecruitingNot ApplicableNCT05652153

Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior


Sponsor

University of Minnesota

Enrollment

80 participants

Start Date

May 25, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure negative urgency and brain signals in adolescents aged 13-21 years with depression and suicidal thoughts and behaviors. The main questions it aims to answer are: * Whether a type of brain signaling called cortical inhibition is related to negative urgency * Whether depressed adolescents with suicidal behavior have more problems with cortical inhibition than depressed adolescents with suicidal thoughts only * Whether the relationship between negative urgency and cortical inhibition changes over time Adolescents who participate in the study will complete the following activities at the time they join the study, as well as 6 months and 12 months later: * Interviews with researchers and questionnaires to learn about their thoughts, emotions, and symptoms * A questionnaire about impulsive behaviors and negative urgency * Computerized games that measure brain functions * An MRI scan of the brain * Transcranial magnetic stimulation with electroencephalography (TMS-EEG), a way to measure how brain cells communicate (cortical inhibition) using a magnet placed outside of the head and recording brain signals


Eligibility

Min Age: 13 YearsMax Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study investigates brain mechanisms involved in impulsive behavior and suicidal thoughts in teenagers and young adults. Using brain imaging, it explores how emotional impulsivity (acting out when upset) relates to self-harm risk. **You may be eligible if...** - You are between 13 and 21 years old - You are willing to participate and a guardian can provide consent if you are under 18 - You can read and understand study materials in English **You may NOT be eligible if...** - You have significant medical conditions that affect brain function - You have metal implants or other conditions preventing MRI - You are currently in acute psychiatric crisis requiring immediate hospitalization Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSingle-/paired-pulse transcranial magnetic stimulation

Single-/paired-pulse transcranial magnetic stimulation (sp/ppTMS) is a technique for noninvasive assessment of brain physiology by delivering single or paired magnetic stimuli to the scalp with an electromagnetic coil. This results in transient induction of cortical electrical activity, which can be measured as evoked potentials by electromyography (EMG) and electroencephalography (EEG). Note that sp/ppTMS is used for neurophysiologic measurements; it is distinct from other TMS applications such as repetitive TMS, which can be used as interventions.


Locations(1)

University of Minnesota

Minneapolis, Minnesota, United States

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NCT05652153


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