RecruitingPhase 1Phase 2NCT05654649

Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section

Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section, Does it Make a Difference: A Randomized Controlled Study


Sponsor

Assiut University

Enrollment

90 participants

Start Date

Dec 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Postoperative ileus is a perplexing problem for clinical surgeons. It occurs not only after abdominal surgery but also after any surgery that requires general anesthesia. Postoperative ileus is defined as the dysfunction of gastrointestinal motility after surgery, characterized by a decrease in, or stagnation of, intestinal peristalsis.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Inclusion Criteria5

  • All participants will sign an informed consent prior to inclusion in the study.
  • All patients 18-40 years of full-term singleton pregnancy (37-41 weeks).,
  • American Society of Anaesthesiologists (ASA) classification class I and II scheduled.
  • for elective or semi-elective surgery (category 3 and 4 Caesarean sections).
  • All patients under spinal anesthesia for a Single baby pregnancy of more than 32 weeks will be included in this study.

Exclusion Criteria4

  • will be patients' height < 150 or > 180 cm.
  • Body mass index (BMI) >35 kg m-2.
  • Contraindication or refusal to undergo regional anesthesia.
  • any cardiovascular disease including arrhythmias and severe stenotic valvular heart disease.any renal or hepatic diseased patients.

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Interventions

DRUG0.9%sodium chloride

Patients received 5 ml of IV normal saline as a placebo just before spinal anesthesia

DRUGDexamethasone

Patients received IV dexamethasone 8 mg in 5ml normal saline 0,9%, just before spinal anesthesia.


Locations(1)

woman health hospital , Assiut university

Asyut, Egypt

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NCT05654649


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