RecruitingNot ApplicableNCT05656469

Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders

A New Intervention for Implementation of Pharmacogenetics in Psychiatry


Sponsor

Maastricht University Medical Center

Enrollment

2,500 participants

Start Date

Feb 23, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

A 24-week, patient- and rater-blinded, two-arm, parallel-group controlled, and multi-centre randomized clinical trial (RCT) to establish the benefits of pharmacogenetics-informed pharmacotherapy versus dosing as usual (DAU) in psychiatric patients suffering from mood, anxiety, or psychotic disorders.


Eligibility

Min Age: 16 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This trial tests whether using your genetic profile (pharmacogenomics) to choose psychiatric medications leads to better treatment outcomes than standard prescribing for depression, anxiety, or psychotic disorders. You may be eligible if... - You have moderate-to-severe depression, anxiety (panic or generalized), or a psychotic disorder (schizophrenia or schizoaffective disorder) - You have had an inadequate response to at least one psychiatric medication in your lifetime - You are switching to (or recently switched to) sertraline or escitalopram (for mood/anxiety), or another specified medication for psychosis You may NOT be eligible if... - You do not meet the diagnostic criteria for the conditions listed above - You have not previously tried at least one psychiatric medication - You are not in the process of switching to one of the study medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPersonalised medication advice based on pharmacogenetic testing

Pharmacogenetic genotyping provides personalised medication advice on dosage and choice of currently available and legally approved medication based on the patient's pharmacogenetic profile


Locations(9)

SUNY Upstate Medical University, Department of Psychiatry and Behavioural Sciences

Syracuse, New York, United States

University Hospital Bonn, Department of Psychiatry and Psychotherapy

Bonn, Germany

Ludwig-Maximilian University, University Hospital, Institute of Psychiatric Phenomics and Genomics (IPPG)

München, Germany

Parnassia Psychiatric Institute, Department of Psychiatry

Amsterdam, Netherlands

Maastricht University, Department of Psychiatry and Neuropsychology

Maastricht, Netherlands

Babeş-Bolyai University, Department of Clinical Psychology and Psychotherapy

Cluj-Napoca, Romania

University of Belgrade, Faculty of Pharmacy

Belgrade, Serbia

Fundació Clínic per a la Recerca Biomèdica, Department of Psychiatry and Psychology, Hospital Clínic

Barcelona, Spain

King's College, Institute of Psychiatry, Psychology & Neuroscience

London, United Kingdom

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NCT05656469


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