RecruitingNot ApplicableNCT05661084

Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

Multifocal Transcranial Current Stimulation for Cognitive and Motor Dysfunction in Dementia


Sponsor

Hebrew SeniorLife

Enrollment

144 participants

Start Date

Jan 24, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.


Eligibility

Min Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study tests a home-based, non-invasive brain stimulation technique (called transcranial electrical stimulation, or tES) to improve memory, thinking, and movement in people living with dementia. A caregiver or family member administers the gentle electrical stimulation at home under researcher guidance. **You may be eligible if...** - You have been diagnosed with dementia - You are willing and able to give informed consent - You can read, write, and communicate in English - You have a caregiver who is comfortable with computers and willing to help administer the brain stimulation at home on weekdays **You may NOT be eligible if...** - You have a major psychiatric condition such as severe depression, schizophrenia, or psychosis - You are blind or have other disabilities that prevent completing the study tasks - You have had a seizure in the past two years - You use neuroactive drugs that might interfere with the stimulation - You have an implanted medical device (e.g., deep brain stimulator, cochlear implant) - You have a skin condition on the scalp - Your cognitive score (MoCA) is 18 or below Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)

Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator to the left angular gyrus and prefrontal cortex.

DEVICETranscranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham)

A sham transcranial electrical stimulation (tES) will be administered to the participant in their home by their caregiver administrator to the left angular gyrus and prefrontal cortex. It will physically mimic active stimulation.

DEVICETranscranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham)

Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator. Active tACS to the left angular gyrus and sham tDCS to the prefrontal cortex.

DEVICETranscranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)

Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator. Sham tACS to the left angular gyrus and active tDCS to the prefrontal cortex.


Locations(1)

Hinda and Arthur Marcus Institute for Aging Research

Boston, Massachusetts, United States

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NCT05661084


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