The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action
To Compare the Effects of Intraoperative Use of Intravenous Anesthetics Propofol and Inhaled Anesthetics Sevoflurane on the Prognosis of Patients Undergoing Surgery for Primary Lung Tumors and the Investigation of Its Mechanism of Action.
Kaohsiung Medical University Chung-Ho Memorial Hospital
300 participants
Dec 27, 2022
INTERVENTIONAL
Conditions
Summary
This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary early lung cancer. The study will enroll approximately 300 volunteers to compare the progression-free or overall survival in patients undergoing video-assisted thoracoscopic surgery (VATS) for primary lung tumors between propofol and sevoflurane for the maintenance of anesthesia.
Eligibility
Inclusion Criteria3
- eighteen to eighty-year-old
- ASA class I-III patients
- Received elective thoracic surgery for primary lung tumors under general anesthesia
Exclusion Criteria14
- mental disorder
- poor liver function
- pregnant or lactating women
- morbidly obese
- allergy to any of the drugs used in this study
- recurrent tumor or repeat surgery
- biopsy cases
- incomplete outcome-data
- palliative treatment after surgery
- simultaneous treatment of other malignancies
- emergency surgery
- presence of other malignant tumors
- combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine
- diagnosed as benign lung tumor, or other metastatic lung tumor
Interventions
The propofol group was both induced and maintained at an effect-site concentration (Ce) of 2.0-4.0 mcg/mL by a target-controlled infusion (TCI) system.
The sevoflurane group was maintained via sevoflurane vaporizer between 1% and 3% (target minimum alveolar concentration of 0.7-1.3 MAC)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05663242