RecruitingPhase 4NCT05663242

The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action

To Compare the Effects of Intraoperative Use of Intravenous Anesthetics Propofol and Inhaled Anesthetics Sevoflurane on the Prognosis of Patients Undergoing Surgery for Primary Lung Tumors and the Investigation of Its Mechanism of Action.


Sponsor

Kaohsiung Medical University Chung-Ho Memorial Hospital

Enrollment

300 participants

Start Date

Dec 27, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary early lung cancer. The study will enroll approximately 300 volunteers to compare the progression-free or overall survival in patients undergoing video-assisted thoracoscopic surgery (VATS) for primary lung tumors between propofol and sevoflurane for the maintenance of anesthesia.


Eligibility

Min Age: 20 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether the type of anesthesia used during lung cancer surgery affects long-term outcomes such as cancer recurrence and survival. Researchers are collecting data from patients who underwent surgery to compare different anesthetic approaches. **You may be eligible if...** - You are 18–80 years old - You have a primary lung tumor being removed with planned thoracic (chest) surgery under general anesthesia - Your surgery is elective (scheduled in advance, not an emergency) - You are in ASA health class I, II, or III **You may NOT be eligible if...** - You have a mental disorder - You have significant liver problems - You are pregnant or breastfeeding - You are severely obese - You are allergic to any of the medications used in this study - This is a repeat surgery for a recurring tumor - Your tumor was found to be benign, a metastasis from another cancer, or the surgery was for biopsy only - You received another cancer treatment (like chemotherapy) before surgery - Your surgery was changed to palliative (non-curative) during the operation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPropofol

The propofol group was both induced and maintained at an effect-site concentration (Ce) of 2.0-4.0 mcg/mL by a target-controlled infusion (TCI) system.

DRUGSevoflurane

The sevoflurane group was maintained via sevoflurane vaporizer between 1% and 3% (target minimum alveolar concentration of 0.7-1.3 MAC)


Locations(1)

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan

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NCT05663242


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