RecruitingPhase 1Phase 2NCT05664178

Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology

Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology (Remote REPS - GI)

Sponsor

H. Lee Moffitt Cancer Center and Research Institute

Enrollment

100 participants

Start Date

Feb 20, 2023

Study Type

INTERVENTIONAL

Conditions

Gastrointestinal Cancer

Summary

The purpose of the study is to evaluate a tele-resistance training exercise program for individuals undergoing chemotherapy for advanced upper gastrointestinal cancer.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Age ≥ 18 years
Biopsy-proven upper GI cancer, stage III-IV
ECOG performance status 0-1
Treatment plan of chemotherapy with planned return to Moffitt Cancer Center for restaging
Able to read and speak English fluently
Capable of providing informed consent

Exclusion Criteria6

Regular engagement in RT (2x/week targeting all major muscle groups)
Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q) and Patient-Reported Measurement Information System (PROMIS) screening questions
Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV).
Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT
Numeric pain rating scale of ≥ 7 out of 10
Myopathic or rheumatologic disease that impacts physical function

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Interventions

BEHAVIORALTele-Resistance Training

Tele-Resistance training sessions will be supervised and guided by a certified exercise trainer via smartphone, tablet or laptop. Exercises will be performed using resistance tubes (Bodylastics Resistance Bands Set) and a connectable bar (Bionic Body Workout Bar) that mimics a weighted barbell when tubes are attached. The tubes provide up to 142 pounds of resistance (adjustable in increments between 3-10 pounds) when simultaneously connected to handles or bar, and multiple tubes can be attached simultaneously. Participants will engage in brief warm up exercises lasting 2-3 minutes prior to each RT session and will rest at least 1 minute between sets of the same exercise to aid muscle recovery. Participants will perform at least 2 sets of 12 repetitions for each of 6 exercises. Including warm up, training sets, and rest, sessions will last approximately 30 minutes. RT will include six target exercises focusing on major muscle groups of the upper body, lower body, and core.