Gastrointestinal Cancer Clinical Trials

58 recruiting

Gastrointestinal Cancer Trials at a Glance

71 actively recruiting trials for gastrointestinal cancer are listed on ClinicalTrialsFinder across 6 cities in 26 countries. The largest study group is Not Applicable with 26 trials, with the heaviest enrollment activity in Bethesda, Philadelphia, and Boston. Lead sponsors running gastrointestinal cancer studies include National Cancer Institute (NCI), Dana-Farber Cancer Institute, and Cedars-Sinai Medical Center.

Browse gastrointestinal cancer trials by phase

Treatments under study

About Gastrointestinal Cancer Clinical Trials

Looking for clinical trials for Gastrointestinal Cancer? There are currently 58 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Gastrointestinal Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Gastrointestinal Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 71 trials

Recruiting

DESTINY-PANTUMOUR04

Liver CancerEsophageal CancerPancreatic Cancer+24 more
AstraZeneca100 enrolled17 locationsNCT07124000
Recruiting

Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery

Gastrointestinal Cancer
The Guthrie Clinic100 enrolled2 locationsNCT05694338
Recruiting

Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer

Gastrointestinal CancerCancer of Gastrointestinal TractNon-GI Cancers
National Cancer Institute (NCI)550 enrolled1 locationNCT01313442
Recruiting
Not Applicable

BOLSTER: Learning New Skills to Thrive

Advanced CancerGynecologic CancerGastrointestinal Cancer
Dana-Farber Cancer Institute600 enrolled2 locationsNCT06936878
Recruiting
Phase 1Phase 2

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Pancreatic CancerGastric CancerColon Cancer+2 more
National Cancer Institute (NCI)110 enrolled1 locationNCT03190941
Recruiting
Not Applicable

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Breast CancerHead and Neck CancerGastrointestinal Cancer+2 more
University of Chicago860 enrolled1 locationNCT04541381
Recruiting
Phase 1Phase 2

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

Gastrointestinal Cancer
Merck Sharp & Dohme LLC180 enrolled62 locationsNCT06596694
Recruiting
Phase 1Phase 2

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

Hepatocellular CarcinomaNeuroendocrine TumorsGastrointestinal Cancer Metastatic
Teclison Ltd.25 enrolled2 locationsNCT02174549
Recruiting
Phase 2

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

Gastrointestinal Cancer
Memorial Sloan Kettering Cancer Center216 enrolled8 locationsNCT05789485
Recruiting
Phase 1

Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

Ovarian CancerPeritoneal CarcinomatosisGastrointestinal Cancer+3 more
National Cancer Institute (NCI)60 enrolled1 locationNCT04847063
Recruiting

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

Breast CancerLung CancerMelanoma+7 more
University Health Network, Toronto7,000 enrolled1 locationNCT07524114
Recruiting
Phase 1

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Breast CancerOvarian CancerProstate Cancer+6 more
Nammi Therapeutics Inc100 enrolled10 locationsNCT06582017
Recruiting
Not Applicable

Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals

Risk of Breast CancerRisk of Gynaecological CancerRisk of Colorectal Cancer+14 more
Gustave Roussy, Cancer Campus, Grand Paris5,909 enrolled1 locationNCT06907095
Recruiting

Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

SarcomaGastrointestinal Cancer
UNC Lineberger Comprehensive Cancer Center180 enrolled1 locationNCT05743426
Recruiting
Not Applicable

Resilience and Equity in Aging, Cancer, and Health (REACH)

Esophageal CancerPancreatic CancerGastric Cancer+3 more
Dana-Farber Cancer Institute257 enrolled1 locationNCT04674267
Recruiting
Not Applicable

Feasibility Study of CBCT for IGRT in Cancer Patients

Breast CancerLiver CancerHead and Neck Cancers+3 more
Varian, a Siemens Healthineers Company50 enrolled4 locationsNCT06681233
Recruiting
Not Applicable

Pilot Randomized Clinical Trial of Informational Support Versus Spiritual Care

Stage IV Lung CancerStage IV Gastrointestinal Cancer
Indiana University36 enrolled4 locationsNCT07176559
Recruiting
Not Applicable

Dyadic Sleep Study

Gastrointestinal Cancer
University of Miami152 enrolled2 locationsNCT06569693
Recruiting
Phase 1

A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6

Pancreatic CancerLung CancerGastrointestinal Cancer
Boehringer Ingelheim97 enrolled7 locationsNCT06091930
Recruiting

Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery

SarcopeniaGastrointestinal CancerNeuromuscular Blockade
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital100 enrolled1 locationNCT07003061