Gastrointestinal Cancer Clinical Trials

82 recruitingLast updated: June 17, 2026

There are 82 actively recruiting gastrointestinal cancer clinical trials across 28 countries. Studies span Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3, Phase 4. Top locations include Toronto, Ontario, Canada, New York, New York, United States, Philadelphia, Pennsylvania, United States. Updated daily from ClinicalTrials.gov.


Gastrointestinal Cancer Trials at a Glance

82 actively recruiting trials for gastrointestinal cancer are listed on ClinicalTrialsFinder across 6 cities in 28 countries. The largest study group is Not Applicable with 30 trials, with the heaviest enrollment activity in Toronto, New York, and Philadelphia. Lead sponsors running gastrointestinal cancer studies include National Cancer Institute (NCI), University Health Network, Toronto, and Dana-Farber Cancer Institute.

Browse gastrointestinal cancer trials by phase

Treatments under study

About Gastrointestinal Cancer Clinical Trials

Looking for clinical trials for Gastrointestinal Cancer? There are currently 64 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Gastrointestinal Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Gastrointestinal Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 82 trials

Recruiting
Phase 1Phase 2

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

Gastrointestinal Cancer
Merck Sharp & Dohme LLC180 enrolled62 locationsNCT06596694
Recruiting
Not Applicable

Personalized Health Self-Management Training for Colorectal Cancer Survivors

Colorectal, CancerGastrointestinal CancersHealth Behavior+2 more
University of Southern California120 enrolled2 locationsNCT05984589
Recruiting
Phase 2

Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.

Gynecologic CancersEsophageal CancerGastrointestinal Cancers
John Waters50 enrolled1 locationNCT07039526
Recruiting

Ontario-wide Cancer TArgeted Nucleic Acid Evaluation

Breast CancerColorectal, CancerLung Cancer+8 more
University Health Network, Toronto10,000 enrolled7 locationsNCT02906943
Recruiting
Phase 2

Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) Cancers

Gastrointestinal Cancers
Genmab160 enrolled2 locationsNCT07539311
Recruiting

DESTINY-PANTUMOUR04

Liver CancerEsophageal CancerPancreatic Cancer+24 more
AstraZeneca100 enrolled17 locationsNCT07124000
Recruiting
Phase 1Phase 2

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Pancreatic CancerGastric CancerColon Cancer+2 more
National Cancer Institute (NCI)110 enrolled1 locationNCT03190941
Recruiting

Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer

Gastrointestinal CancerCancer of Gastrointestinal TractNon-GI Cancers
National Cancer Institute (NCI)550 enrolled1 locationNCT01313442
Recruiting
Phase 1Phase 2

A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors

Gastrointestinal Cancer
DualityBio Inc.127 enrolled9 locationsNCT07263594
Recruiting
Not Applicable

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

Liver CancerEsophageal CancerColon Cancer+7 more
Case Comprehensive Cancer Center200 enrolled1 locationNCT06263088
Recruiting
Not Applicable

Exercise Training After Upper Gastrointestinal Cancer Surgery

Upper gastrointestinal cancerEsophageal CancerGastric Cancer (Diagnosis)
Kansai Medical University171 enrolled2 locationsNCT07561840
Recruiting

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

Breast CancerLung CancerMelanoma+7 more
University Health Network, Toronto7,000 enrolled1 locationNCT07524114
Recruiting

Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery

Gastrointestinal Cancer
The Guthrie Clinic100 enrolled2 locationsNCT05694338
Recruiting
Not Applicable

BOLSTER: Learning New Skills to Thrive

Advanced CancerGynecologic CancerGastrointestinal Cancer
Dana-Farber Cancer Institute600 enrolled2 locationsNCT06936878
Recruiting
Not Applicable

Extracellular Vesicles and Chemotherapy-Induced Peripheral Neuropathy

Breast CancerLung CancerHead and Neck Cancer+3 more
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico120 enrolled1 locationNCT07558447
Recruiting
Not Applicable

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Breast CancerHead and Neck CancerGastrointestinal Cancer+2 more
University of Chicago860 enrolled1 locationNCT04541381
Recruiting
Phase 2

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

Gastrointestinal Cancer
Memorial Sloan Kettering Cancer Center216 enrolled8 locationsNCT05789485
Recruiting
Phase 1Phase 2

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

Hepatocellular CarcinomaNeuroendocrine TumorsGastrointestinal Cancer Metastatic
Teclison Ltd.25 enrolled2 locationsNCT02174549
Recruiting
Phase 1

Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

Colorectal, CancerOvarian CancerPeritoneal Carcinomatosis+4 more
National Cancer Institute (NCI)60 enrolled1 locationNCT04847063
Recruiting
Phase 1

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Breast CancerOvarian CancerProstate Cancer+6 more
Nammi Therapeutics Inc100 enrolled10 locationsNCT06582017