Glutamate Inhibitors in Glioblastoma

This study tests whether adding glutamate inhibitors (drugs that block a brain chemical called glutamate) to standard treatment improves outcomes for people with newly diagnosed glioblastoma — the most serious type of brain tumor. Standard treatment includes surgery, radiation, and a chemotherapy called temozolomide. **You may be eligible if...** - You are over 18 years old - You have been newly diagnosed with glioblastoma (as defined by 2021 WHO criteria) - You are eligible for standard chemoradiotherapy with temozolomide - Your performance score (Karnofsky Performance Status) is 70 or higher — meaning you can carry out normal activities with some effort - Your blood, liver, and kidney function are within acceptable ranges - Tumor tissue is available for central review **You may NOT be eligible if...** - You are scheduled for a shorter, hypofractionated radiation regimen - You are pregnant or breastfeeding, or planning a pregnancy - You have other significant medical conditions (serious kidney, liver, or heart disease) - You have a known allergy to the study drugs - You are unable to use effective contraception Talk to your doctor to see if this trial is right for you.