A PiLot ClinicaL TrIal of ParicAlcitol for ChroNiC PancrEatitis

This pilot study tests whether paricalcitol, a synthetic form of vitamin D, can safely reduce pain and improve quality of life in adults with chronic pancreatitis — a condition involving long-term inflammation of the pancreas. Laboratory research suggests vitamin D analogues may help by blocking proteins involved in inflammation, and this study will explore whether those benefits translate to human patients. Eligible participants are 18–75 years old with a diagnosis of chronic pancreatitis not caused by gallstones, medications, or autoimmune disease, and with normal calcium, phosphate, and parathyroid hormone levels. The study involves taking the study drug or a placebo for 12 months, with MRI scans, bone density scans, blood tests, and follow-up visits at the start, middle, and end of the study. This summary was prepared to help patients understand the study in plain language.