Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung Cancer

This study collects blood samples (liquid biopsies) and tissue from people with early-stage lung cancer before and after treatment, to develop better blood-based tests for detecting cancer recurrence earlier and monitoring long-term outcomes without repeated invasive procedures. **You may be eligible if...** - You are 18 or older - You have a lung nodule between 8–40 mm that is suspected to be an early-stage (Stage IA or IB) lung cancer - You are planning to have surgery or radiation therapy (SBRT) at Moffitt Cancer Center - You are in good health (ECOG 0–1) - You agree to participate in follow-up visits over time **You may NOT be eligible if...** - You are currently receiving any cancer treatment - You have another active major cancer (other than non-melanoma skin cancer) - You had a previous lung cancer diagnosis within the past 5 years - Your lung nodule is a pure ground glass opacity, a suspected carcinoid, a benign tumor, or a metastasis from another cancer - You are incarcerated or unable to give informed consent Talk to your doctor to see if this trial is right for you.