InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

This study is building a long-term research registry to monitor, prevent, and catch cancer early in people who are at higher-than-average cancer risk due to genetics, family history, or pre-cancerous conditions. Rather than testing a treatment, this study collects data over time to learn what works best for surveillance and early interception of cancer. **You may be eligible if...** - You carry a gene mutation that raises cancer risk (e.g., BRCA1/2, Lynch syndrome genes, TP53) - You have a strong personal or family history suggestive of hereditary cancer - You have a diagnosed pre-cancerous condition (e.g., Barrett's esophagus, colorectal polyps, MGUS, lobular carcinoma in situ) - You have another condition known to predispose to cancer (e.g., Li-Fraumeni syndrome, Gorlin syndrome) **You may NOT be eligible if...** - You currently have active cancer requiring treatment - You do not have any identifiable elevated cancer risk factor Talk to your doctor to see if this trial is right for you.