PRP for Glenohumeral Osteoarthritis

This study tests whether injecting platelet-rich plasma (PRP, derived from a patient's own blood) into the shoulder joint helps reduce pain from glenohumeral osteoarthritis (wear-and-tear of the main shoulder joint). It compares outcomes over time to see if PRP provides lasting pain relief. You may be eligible if... - You are between 18 and 100 years old - You have shoulder joint arthritis confirmed on MRI - Your average shoulder pain is at least 5/10 - You have had shoulder pain for at least 3 months that has not improved with physical therapy - You experienced temporary pain relief after a diagnostic shoulder injection - You have access to email You may NOT be eligible if... - You cannot stop taking anti-inflammatory drugs (NSAIDs) for 2 weeks before and 1 month after the injection - You have already had a PRP injection in the shoulder - You had a steroid injection in the past 3 months or hyaluronic acid in the past 6 months - You are involved in workers' compensation or active litigation related to the shoulder - You take Plavix (clopidogrel) - You have uncontrolled diabetes, HIV, vasculitis, or autoimmune disease - You have an acute fracture or major structural deformity of the shoulder - You have uncontrolled cervical (neck) spine disorders Talk to your doctor about your shoulder imaging results, current medications, and prior injections before considering this study.