Biological Signatures Resulting From Occupational Exposure to Complex Mixtures of PAHs
Biological Signatures (Proteomics, Metabolomics and Genotoxicity) Associated With Occupational Exposure to PAH Mixtures and Relation With Exposure Biomarkers: Support for the Derivation of Biological Limit Values
University Hospital, Grenoble
100 participants
Apr 25, 2023
INTERVENTIONAL
Conditions
Summary
This research project aims at better understanding the early biological effects resulting from occupational exposure to complex Polycyclic Aromatic Hydrocarbon (PAH) mixtures. Current biomarkers used as part of biomonitoring campaigns are biomarkers of exposure, not numerous and poorly related to health effects. The aim of this study is thus to improve our understanding of biological consequences of such exposures, both in terms of proteins deregulation, metabolism deregulation and genotoxicity.
Eligibility
Inclusion Criteria4
- Subjects ages 18 years or more
- Subjects occupationally exposed to PAHs since more than 3 months
- Having signed the informed consent
- recruited by the occupational health service
Exclusion Criteria3
- Obesity (BMI>30)
- Subjects suffering cancers or metabolic diseases (diabetes, dyslipidemia, amino-acid diseases, renal or hepatic impairment) at the onset of the study.
- Subjects taking medications related to the above diseases at the onset of the study.
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Interventions
Biological samples collected in period of exposure and after holidays
Locations(1)
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NCT05679544