RecruitingPhase 3NCT05681312

Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and QoL After Surgical Extraction of Impacted Mandibular Third Molars

Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and Quality of Life After Surgical Extraction of Impacted Mandibular Third Molars

Sponsor

University of Baghdad

Enrollment

55 participants

Start Date

May 8, 2024

Study Type

INTERVENTIONAL

Conditions

Post Operative Pain

Summary

1. To compare the postoperative pain between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 2. To compare the postoperative swelling (edema) between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 3. To compare the degree of trismus between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 4. Measure patients' perceptions of changes in their quality of life in the postoperative period and compare it between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria4

Healthy patients over 18 years old of either gender.
Patients who have impacted mandibular third molar.
Ability to tolerate surgical procedure.
Pell and Gregory's classification (Class I and class II, position A and B).

Exclusion Criteria5

Patients with uncontrolled systemic diseases.
Patients with history of chemotherapy or radiotherapy therapy to the head and neck region.
Acute infection at the surgical site at time of operation.
The presence of cysts or tumors associated with the impacted teeth.
Pell and Gregory's classification (class III Position C)